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Table 3 Summary of statistics for each PD and MSA region

From: Refining α-synuclein seed amplification assays to distinguish Parkinson’s disease from multiple system atrophy

Parameter

Condition

All regions*

Medulla

Substantia nigra

Hippocampus

MTG

Cerebellum

AUC

PD

929,582

854,696

1,117,823

1,120,594

644,040

MSA

2,704,307

2,824,029

2,718,121

2,397,355

2,877,725

Lag time (h)

PD

16.0 ± 5.6

11.9 ± 2.1

16.6 ± 5.1

19.4 ± 6.3

22.3 ± 6.6

MSA

5.07 ± 1.8

4.4 ± 1.2

4.2 ± 1.8

6.7 ± 1.1

3.4 ± 1.2

PAR (h−1)

PD

0.06 ± 0.02

0.086 ± 0.02

0.065 ± 0.02

0.056 ± 0.02

0.049 ± 0.02

MSA

0.25 ± 0.09

0.24 ± 0.06

0.27 ± 0.08

0.15 ± 0.03

0.32 ± 0.09

MRF

PD

26 ± 11

18 ± 5

29 ± 7

31 ± 15

25 ± 11

MSA

47 ± 12

51 ± 15

47 ± 13

48 ± 9

43 ± 12

Gradient

PD

3494 ± 

2475

3639 ± 

2346

4471 ± 

2414

3756 ± 

3107

2209 ± 

1626

 

MSA

16,152 ± 

9649

14,750 ± 

5975

13,594 ± 

8326

10,917 ± 

5110

25,345 ± 

11,769

  1. Data presented as mean ± SD. PAR, protein aggregation rate; MRF, maximum relative fluorescence; MTG, middle temporal gyrus. * Only regions common to both PD and MSA (medulla, substantia nigra, and hippocampus) were included for quantification