Fig. 5
RT-QuIC amplification curves and PK digestion profiles from PD patient-derived CSF. a RT-QuIC amplification curves from PD CSF samples (n = 8) and neurologically normal CSF samples (n = 3). b Comparison of PAR, maximum relative fluorescence, and gradient of amplification across PD brain tissue regions and PD CSF samples. Filled circles (black) denote the mean kinetic values, the crossbars denote the median kinetic values, and the box plot extremities denote the interquartile range. c PK digestion profiles for PD patient-derived CSF samples. MM, middle medulla; SN, substantia nigra; HP, hippocampus; MTG, middle temporal gyrus; CSF, cerebrospinal fluid; PAR, protein aggregation rate